Speaker to Animals wrote: ↑Wed Mar 09, 2022 1:59 pm
TheOneX wrote: ↑Wed Mar 09, 2022 1:39 pm
Also covid is not going to evolve into something more deadly any time soon, if ever. For starters there is a reason why most coronaviruses are considered common colds, because it simply is not in the nature of coronaviruses to evolve to be deadly in humans. It either takes artificially changing the virus or a zoonotic jump to be deadly. Secondly, this variation of covid essentially has the maximum compatible spike protein, which means it is essentially impossible for it to become more transmissible or deadly with its current means of entering cells. In order to become more deadly it would need to essentially evolve a completely different type of spike protein which is not something that is remotely likely to happen any time soon. Add to that the nature of human immune reactions as more people have it the more protected people will be to future variants, making it more difficult for future variants to spread rapidly and be deadly.
(1) I would like to point out that "coronavirus" refers to a suborder of viruses and generally describes a vast number of viruses. The ones that cause the common colds are totally different. It's like saying "well, I'm not afraid of sharks because we all had goldfish when we were kids and we they weren't all that dangerous, right?". These are totally different things.
(2) These meme that viruses necessarily evolve to become benign is fake science bullshit. Sometimes they do. Other times they don't. Examples of when they don't: smallpox, polio, cholera, hantavirus, ebola, marburg virus, and now... *dun* *dun* *dun* *dun* sars-cov-2. With the exception of a single variant (omicron), all the other variants have been more virulent. Alpha was more virulent than the original Wuhan strain; delta more virulent than alpha.
(3) Your analysis mistakenly characterizes the evolution of sars-cov-2 as this linear line; as if the original Wuhan strain became alpha, which became delta, which became omicron. That's not what happened. Obviously the original strain is the common ancestor, but these variants are all branched out now and doing their own things. Maybe omicron will continue spawning off less virulent variants, but that doesn't stop delta from spawning off even more virulent variants, and nothing stops brand new variants from emerging, especially from all the other animal reservoirs out there.
(4) If you want to look at a ceiling of how bad this can get, all of sars-cov-2's nearest cousins, viruses like MERS have case fatality rates near 50%. Nobody knows how many mutations away one of these variants might be from unlocking that kind of potential.
(5) The idea that this virus is merely limited by the spike protein is silly. I know virologists right now are trying to figure out just how omicron can spread so fast. It seems to have found another way to infect cells besides the ACE2 receptor. You are not considering all the possibilities here by assuming the virus can only use the spike protein to infect cells via the ACE2 receptor. Omicron shows us that probably is not true. It seems to be abandoning the ACE2 receptor.
As for the potential receivers of those infectious particles, Barclay suggests that Omicron’s transmission strength might be linked to how it enters cells. Earlier versions of SARS-CoV-2 relied on a cellular receptor, ACE2, to bind to the cells, and on a cellular enzyme called TMPRSS2 to cleave its spike protein, granting the virus entry. Omicron has mostly abandoned the TMPRSS2 route. Instead, cells swallow it whole, and it lands in intracellular bubbles called endosomes2,6.
https://www.nature.com/articles/d41586-022-00428-5
I am resigned to the fact that some kind of killer variant has to kill a lot of people before we actually do anything. I am just kind of bored today and thought I would post here. I think you guys should consider you are talking each other up about the wrong things. The vaccines and all this cable news nonsense is not really worth getting upset about. I think this pandemic might be really dangerous to us. Even at the practical level, I really don't see how we can afford the mass disability wave we will suffer if we don't manage the infection rates better.
1. Yes, coronaviruses is a large family of viruses. Covid is specifically of the beta variety. Other than SARS, MERS, and COVID in humans they all result in just colds. SARS and MERS are both zoonotic cases where transmission was not very good resulting in SARS going extinct and MERS being this enigma that pops up occasionally, but never really catches on.
2. This is one big lie. If you remove all nuance and context you might have a point, but we aren't talking about smallpox or ebola. We are talking about coronaviruses. When we talk about the class of viruses that spread very easily like flus, coronavirus, rhinovirus, and other common colds yes they typically evolve to become less deadly over time. This isn't some meme or fake science, it is rooted in science. There is evolutionary pressure that is applied to these viruses that encourages them to become less deadly. Occasionally, you will get a random mutation that results in a drastic increase in deadliness, but over time it will slowly move back to normalcy. That is why H1N1 isn't as deadly today as it was when it was known as the Spanish Flu.
3. I didn't characterize the evolution in any way. The purpose of my 3 paragraph comment was not to provide a detailed analysis of how the different variants evolved. If I wanted to do that it certainly would take more than 3 paragraphs. This is just a deflection from the actual points I am making, and a non-sequitur.
4. All of sars-cov-2 nearest cousins live in bats and pangolins not humans. MERS is not a close cousin and only has a 35% case fatality rate.
5. Don't quote me shit I already know if you are not able to understand what you are reading. Entering the cell is a multi-step process. The first and most important step is using the spike protein to connect itself to the cell. This is why antibodies and vaccines attack the spike protein to prevent the coronavirus from even attaching itself to the cell in the first place. This step cannot be skipped. The omicron variant still uses the ACE2 receptor to attach itself to the cell. What has changed is the second step in the process. Instead of using the cleavage site it uses a different process, which is what the quote states that Omicron has stopped using the cleavage site, but it never says Omicron has stopped using ACE2. What science has actually shown is that the omicron variant has the most perfect spike protein for attaching itself to ACE2 that we have seen to date.
You can resign yourself however much you want, but you clearly have been listening to liars and fearmongers. A virus evolving to become noticeably more deadly and transmissible. It happens with flus maybe a few times in a century, usually amounting to the swine flu scare from a decade or so ago. You get maybe one big one a century, but societies don't usually collapse over it. Worrying about a black death like scenario is like worrying about the super volcano under Yellowstone going off. Sure it technically could happen, but the likelihood of it happening during your lifetime is so small it says more about your mental state that you are worried about it than the actual chances of it happening. I would highly recommend turning off all media and going to see a psychiatrist or a psychologist, you clearly have some mental issues going on. Watching any news, commentary, or visiting these kinds of sites are doing you more harm than good.