I'm digging Governor DeSantis so far

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Speaker to Animals
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Re: I'm digging Governor DeSantis so far

Post by Speaker to Animals » Sun Jan 27, 2019 8:21 am

Indeed.
Researchers in the Department of Psychiatry at Columbia University have revealed some new findings about the effects of heavy cannabis use — chronic marijuana users have compromised dopamine systems.

Previous research has shown that addiction to other drugs like cocaine and heroin have similar effects on dopamine release, but until now, the evidence for cannabis was missing.

"In light of the more widespread acceptance and use of marijuana, especially by young people, we believe it is important to look more closely at the potentially addictive effects of cannabis on key regions of the brain," said lead author Anissa Abi-Dargham, professor of psychiatry at Columbia University Medical Center (CUMC), in a press statement.
SEE ALSO: Medical Marijuana Could Help You Reduce the Frequency of Your Migraines

The results, which have been published in the journal Molecular Psychiatry, show that heavy cannabis users showed a reduced level of dopamine release in the striatum — a brain region that regulates memory, attention, and impulsive behavior.
http://thescienceexplorer.com/brain-and ... tudy-finds



What are the effects?
Low Dopamine Symptoms: List of Possibilities

Since dopamine is involved in a variety of brain functions, low extracellular levels of this neurotransmitter can result in a variety of unwanted symptoms. Keep in mind that the severity and number of symptoms you experience as a result of low dopamine is subject to individual variation.

Attention deficits: Many individuals with attentional deficits are speculated to have abnormally low levels of dopamine. If you have below average levels of dopamine, it’s going to make it tougher to pay attention and focus. We know that administration of amphetamines (drugs which elevate dopamine) is able to improve attentional capacities of individuals who struggle with attention. Low dopamine may not be the sole reason for attention deficits, but those with lower than average dopamine will likely struggle to focus their attention.
Anxiety: Those with anxiety disorders have probably heard that high dopamine can exacerbate nervousness, tension, and anxiety. Certainly higher than average dopamine can be problematic, but abnormally low dopamine causes anxiety in a subset of individuals. These individuals often find that taking a drug like Adderall for anxiety actually improves their symptoms.
Blunted affect: A decrease in the level of dopamine often results in a person to appear “blunted” or as if they have emotionally flat-lined. They won’t show much capacity for expressing feelings of joy, excitement, happiness, but they also won’t really express sadness or panic. Low dopamine causes a person to appear emotionally “grey” or as if they’ve become a robot.
Cognitive impairment: It’s tough to perform well cognitively when you don’t have enough dopamine. Insufficient dopamine can result in suboptimal job performance, inability to complete cognitively-demanding tasks, and poor memory. As a means to optimize dopamine levels, many top-performers supplement agents or drugs that deliberately elevate their brain’s baseline dopamine level.
Confusion: It’s relatively easy to become confused when your brain isn’t producing enough dopamine. Learning new things won’t make as much sense as they should, you may experience excessive brain fog, and have a difficult time functioning in society. Increasing dopamine tends to decrease confusion and promotes psychomotor vigilance.
Depersonalization: Dopamine promotes emotional expression and helps us process how we feel. With low levels of dopamine, it may feel as if all of the color and zest gets sucked out of life. A person with dopaminergic-based depersonalization may feel as if no activity brings them pleasure. They feel as if their “core” personality has changed and as if they are observing themselves from a third-person perspective. It is common for addicts with low dopamine to become depersonalized.
Depression: Low dopamine can be a major contributor to depressive symptoms. Anyone with abnormally low dopamine is likely to experience a depression that differs from a serotonergic depression, despite the fact that both share common overt observational symptoms. Those that end up taking a drug like Adderall for depression over a long-term with success may have needed a dopamine boost rather than serotonin.
Disorganized thinking: Those who have severely disorganized thinking tend to have low levels of dopamine. Sufficient dopamine helps us organize and logically sort through our thoughts. Those that develop conditions like disorganized schizophrenia may have abnormally low dopamine in certain parts of the brain.
Fatigue: Without enough dopamine for fuel, you may feel excessively tired or lethargic. When a person that’s been using amphetamines daily for an extended term stops using them, they typically feel more tired than usual. This is a fatigue that’s directly influenced by abnormally low levels of dopamine. Over time without a relapse, the dopamine stores will increase and energy levels will normalize.
Lack of motivation: Low dopamine can also lead to avolition or severe motivational deficits. Slightly reduced dopamine production may make you feel more tired than usual and feel lazy. Severe deficits can result in motivational impairment to the point that it’s difficult to justify doing work or engaging in proper self-care.
Learning problems: If you’re a person with low dopamine and are attempting to learn new information, your ability to learn is diminished. It may seem as if you’re reading or hearing information, but it’s going in one ear and out the other. Almost like you cannot absorb the new informational stimuli that you’ve presented your brain.
Poor concentration: You may have foggy thinking, be susceptible to daydreams, and have a tough time focusing when necessary. Low dopamine can create a state of mental fogginess, making it tougher than usual to concentrate. This is why those with concentration problems often find that ADHD medications (or psychostimulants) improve their ability to focus.
Inattentiveness: Those with the inattentive subtype of ADHD may get the most benefit from increasing their dopamine. While low dopamine certainly isn’t the only factor that causes inattentiveness, it likely plays a role. Inattentiveness can sometimes be offset by increasing extracellular levels of dopamine.
Low libido: A person with low dopamine tends to have a reduced interest in sex. They may have less desire to seek out a sexual partner and may have a non-existent sex drive. In some cases anorgasmia or inability to orgasm may result due to the fact that they lack dopamine to sustain interest. Low libido tends to quickly turn around when dopamine levels increase.
Memory impairment: Those with neurodegenerative diseases often suffer memory impairment as a result of dysfunction within the brain’s dopamine system. The dysfunction results in abnormally low amounts of dopamine and memory functions become impaired. While low dopamine certainly isn’t the only cause of memory problems, increasing dopamine (via pharmaceuticals) tends to help improve recall.
Monotone speech: A person’s speech may become extremely monotone, which is indicative of the fact that they are lacking pleasure. Life isn’t really as “bright” as it should be when dopamine levels are low. Voices of those with low dopamine may sound robotic and lack any emotional enthusiasm in a positive or negative direction. This is associated with blunted affect which was mentioned earlier.
Sleepiness: If your dopamine levels are low, you may feel more sleepy than usual. It isn’t uncommon to engage in excessive sleep as a way for your brain to increase dopamine production. Those withdrawing from stimulatory drugs like amphetamines typically notice that they are more sleepy than usual upon discontinuation. This is due to the fact that their dopamine levels are below baseline.
Slow thinking: While thinking slow can sometimes be a result of preexisting genetically homeostatic neural pathways, it can also be a result of a dopamine deficiency. Those that consider themselves “slow thinkers” may find that their thinking is further slowed with reduced dopamine. Increasing dopamine tends to increase arousal, beta brain waves, and thought speed.
Social withdrawal: Since low dopamine saps the pleasure from life, it is common for those with low levels to withdraw from social situations. A person may no longer get pleasure from talking to friends, partaking in social activities, etc. The dopaminergic “feel good” reward from engaging with others in social situations is no longer present. This can provoke social isolation, which over time, can also result in poorer functioning of dopamine.
Weight changes: Generally a person with low dopamine may not derive as much interest in eating food as someone with greater production of dopamine. However, most people with low dopamine find that their metabolism is slowed, they sleep more than usual, and have a difficult time sustaining physical activity. This usually results in weight gain whereas higher dopamine production tends to stimulate weight loss.
https://mentalhealthdaily.com/2015/04/0 ... reactions/


Reads like a description of pothead to me..

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Fife
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Re: I'm digging Governor DeSantis so far

Post by Fife » Sun Jan 27, 2019 9:05 am

OK, you're the supplement guru. What supplements / foods are best for dopamine boosts?

I know how I feel after strenuous exercise, after a good outing at the firing range, practicing with my bow, a successful hunting trip, especially entertaining sex, &c.

Smoking dope 25+ years ago never gave me any feeling like those.

What supplements support dopamine?

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Speaker to Animals
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Re: I'm digging Governor DeSantis so far

Post by Speaker to Animals » Sun Jan 27, 2019 9:53 am

Fife wrote:
Sun Jan 27, 2019 9:05 am
OK, you're the supplement guru. What supplements / foods are best for dopamine boosts?

I know how I feel after strenuous exercise, after a good outing at the firing range, practicing with my bow, a successful hunting trip, especially entertaining sex, &c.

Smoking dope 25+ years ago never gave me any feeling like those.

What supplements support dopamine?
Not sure about supplements. Just stop doing drugs and go to the gym, I suppose.

In my experience, I at least feel like I received the highest dopamine boost when doing hand-balancing work, gymnastic rings, and any kind of acrobatic-type exercise. I am not sure if research shows a better boost from other types of exercises. I know the simple barbell squat has a lot of hormonal results. Maybe it helps dopamine too.

heydaralon
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Re: I'm digging Governor DeSantis so far

Post by heydaralon » Sun Jan 27, 2019 10:45 am

If your dopamine starts to get lowered from smoking weed too often, you need to find a way to increase your dopamine levels in a safe way. I would recommend doing a small amount of fentanyl until you understand how it will react with your body, and then increasing the dosage. Again, it is important to understand how these chemicals work with your body. While Sativa and Indica are more a mental dependence, Fentanyl is more a physical dependence. As far that goes, you should wait at least a few hours between each use with the fentanyl in order to avoid getting your dopamine levels too out of whack. Its important to also eat lots of amino acids and b vitamins as well. You should talk to a doctor or health specialist and explain to them your problem and see if they will prescribe you some fentanyl.
Shikata ga nai

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Fife
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Re: I'm digging Governor DeSantis so far

Post by Fife » Sun Jan 27, 2019 11:14 am

Lots of Doritos and Taco Bell probably help out also.

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DBTrek
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Re: I'm digging Governor DeSantis so far

Post by DBTrek » Wed Jan 30, 2019 10:56 am

As dangerous as weed, if not more so, cats:
Mind-altering parasite spread by CATS and carried by billions of people worldwide 'may lead to schizophrenia in humans'

...Toxoplasma gondii (T. gondii), which can spread to people through contact with cat litter trays and eating uncooked meat, is usually harmless.

But now, the largest study of its kind, has found having the parasite could raise the risk of developing schizophrenia by 50 per cent.

Unusual links between T. gondii and mind-altering behaviour, such as risk-taking, depression and car accidents, already exist. ...
https://www.dailymail.co.uk/health/arti ... renia.html

Looking forward to the new government bureaucracy, felony laws, and armed agents deployed to save us from the scourge of felines destroying our youth.

Talk about Puritanism.
"Hey varmints, don't mess with a guy that's riding a buffalo"

heydaralon
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Re: I'm digging Governor DeSantis so far

Post by heydaralon » Wed Jan 30, 2019 11:01 am

I remember Rogan talking about this years ago.They have done studies on that, and some of them draw correlation between carriers with high instances of bar brawls and motorcycle accidents. It (possibly) makes them more aggressive. To be honest, I'd like that shit to be over the counter, maybe in some kind of inhaler form. You huff some of it right before a big date, or going into your boss's office asking for a promotion. Its a lite version of the movie Limitless.
Shikata ga nai

Kath
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Re: I'm digging Governor DeSantis so far

Post by Kath » Tue Feb 19, 2019 12:19 pm

clubgop wrote:
Sat Jan 26, 2019 5:33 pm
Toke up, get them munchies, I'll have your statins and insulin ready for you.
Name your shop, "Weed ~n~ Feed."
Why are all the Gods such vicious cunts? Where's the God of tits and wine?

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clubgop
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Re: I'm digging Governor DeSantis so far

Post by clubgop » Tue Feb 19, 2019 4:57 pm

Kath wrote:
Tue Feb 19, 2019 12:19 pm
clubgop wrote:
Sat Jan 26, 2019 5:33 pm
Toke up, get them munchies, I'll have your statins and insulin ready for you.
Name your shop, "Weed ~n~ Feed."
State regs say a dispensary has to be a separate business with separate premises. And cash only, credit cards and FDIC banks won't play along.

Kath
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Re: I'm digging Governor DeSantis so far

Post by Kath » Wed Feb 20, 2019 6:46 am

clubgop wrote:
Tue Feb 19, 2019 4:57 pm

State regs say a dispensary has to be a separate business with separate premises. And cash only, credit cards and FDIC banks won't play along.
I know. It's still a clever name.

It'll be fun to see how the different states handle this issue. I'm thinking of states where you can't sell vodka and beer at the same establishment, and if you do sell vodka, you can't sell candy bars or soda. The madness will continue unless the masses start valuing freedom, again.
Why are all the Gods such vicious cunts? Where's the God of tits and wine?